6 RESULTS
COMMENT This paper provides a crucial window into the pathology of AD. The results appear to imply that tau is more directly related to cognitive decline than Aβ, and that developing therapeutics directed at abrogating tau might more likely to impede dementia tha
COMMENT This is a very interesting research letter. Past papers on the subject have described a putative inverse association with dementia as well as extreme manifestations of possible psychiatric illness, such as suicide and homicide, and other, subtler psychiat
COMMENT This is a very interesting finding that reinforces the therapeutic potential of lithium. Like any medication, lithium has a therapeutic window. What is not in dispute is that at high doses used to treat bipolar disorder, the effect of lithium on neurons i
COMMENT A line of evidence suggests that a contributing factor to sporadic Alzheimer’s disease, that may potentially influence amyloidogeneis upstream of amyloid accumulations, is abnormally elevated activity in default mode network (DMN) neurons during cognitive
COMMENT While the APP-KI model offers an invaluable lens for elucidating insights on how amyloid influences neurons and disease cascades downstream of amyloid, an important objective is the identification of candidate therapeutics that modify disease progression
COMMENT A possible physiological explanation for the inverse relationship between cognition and dementia that is worthy of consideration derives from the models of Raichle et al., 2001; Buckner et al., 2005, 2008; Cirrito et al, 2005; and Bero et al., 2011, on th
